Josefina Cruzat Grand

Josefina Cruzat Grand

Doctor en Neurociencia Teórica y Computacional
Investigadora del Instituto Latinoamericano de Salud Cerebral (Brainlat)
Profesor Asistente
GLOBAL BRAIN HEALTH LATAM
CHILE
Stgo
Email: [email protected]

Josefina Cruzat Grand

Doctor en Neurociencia Teórica y Computacional
  • Fonoaudióloga de la Universidad Andrés Bello. 
  • Magíster en Neuropsicología y Neurología de la Conducta de la Universidad Autónoma de Barcelona. 
  • Magíster en Neurociencia y Cognición de la Universitat Pompeu Fabra. 
  • Doctor en Neurociencia Teórica y Computacional de la Universidad Pompeu Fabra, Barcelona, España.

Actualmente es investigadora del Instituto Latinoamericano de Salud Cerebral (Brainlat) en la Universidad Adolfo Ibáñez. Su trabajo se centra en caracterizar los mecanismos y principios computacionales fundamentales subyacentes a los distintos estados cerebrales, y como estos se ven afectados en las enfermedades neuropsiquiátrica y en los estados alterados de conciencias; con la esperanza de ofrecer nuevas vías para el tratamiento de los estados mentales disfuncionales. Su investigación integra modelos matemáticos de gran escala con métodos de análisis avanzados aplicados a datos de neuroimagen multimodal, neurofisiología y neuropsicología.

A multi-frequency whole-brain neural mass model with homeostatic feedback inhibition</>

Coronel-Oliveros, C., Lehue, F., Herzog, R., Mindlin, I., Gatica, M., Kowalczyk-Grębska, N., Medel, V., Cruzat, J., Gonzalez-Gomez, R., Hernandez, H., Tagliazucchi, E., Prado, P., Orio, P. & Ibáñez, A., may. 2026, In: PLoS ONE, 22, 5.

Correction</>

Lavretsky, H., Khalsa, S., Oughli, H., Ibanez, A., Cruzat, J., Edwards, E., Newhouse, P., Bassetti, C., Begue, I., Winkler, A., Jeste, D. & Eyre, H., 2026, In: Neuropsychopharmacology, 51, 7, p. 1347-1348.

The role of brain health and resilience in reshaping trajectories of late-life neuropsychiatric disorders</>

Lavretsky, H., Khalsa, S., Oughli, H., Ibanez, A., Cruzat, J., Edwards, E., Newhouse, P., Bassetti, C., Begue, I., Winkler, A., Jeste, D. & Eyre, H., 2026, In: Neuropsychopharmacology.

Dementia prevention requires moving beyond individual choice</>

Migeot, J., Araya-Ríos, D., Montecinos, M., Baez, S., Behrens, M., Castaner, O., Cruzat, J., Delgado, C., De Jong-Bambagioni, D., Duran-Aniotz, C., Durón Reyes, D., Evans, T., Gonzalez-Gomez, R., Gutiérrez, M., Hayden, K., Hernandez, H., Ibanez, A., Legaz, A., Miller, J., Mačiulskytė, S., Putthinun, P., Santamaría-García, H., Slachevsky, A. & Trépel, D., nov. 2025, In: Neuroscience, 589, p. 256-267.

Qualitative and quantitative educational disparities and brain signatures in healthy aging and dementia across global settings</>

Gonzalez-Gomez, R., Cruzat, J., Hernández, H., Migeot, J., Legaz, A., Santamaria-García, H., Fittipaldi, S., Maito, M., Medel, V., Tagliazucchi, E., Barttfeld, P., Franco-O'Byrne, D., Castro Laguardia, A., Borquez, P., Avila-Funes, J., Behrens, M., Custodio, N., Farombi, T., García, A., Garcia-Cordero, I., Godoy, M., Campo, C., Hu, K., Lawlor, B., Matallana, D., Miller, B., Okada de Oliveira, M., Pina-Escudero, S., de Paula França Resende, E., Reyes, P., Slachevsky, A., Takada, L., Yener, G., Coronel-Oliveros, C. & Ibañez, A., abr. 2025, In: eClinicalMedicine, 82.

Alpha rhythm and Alzheimer's disease</>

Babiloni, C., Arakaki, X., Baez, S., Barry, R., Benussi, A., Blinowska, K., Bonanni, L., Borroni, B., Bayard, J., Bruno, G., Cacciotti, A., Carducci, F., Carino, J., Carpi, M., Conte, A., Cruzat, J., D'Antonio, F., Della Penna, S., Del Percio, C., De Sanctis, P., Escudero, J., Fabbrini, G., Farina, F., Fraga, F., Fuhr, P., Gschwandtner, U., Güntekin, B., Guo, Y., Hajos, M., Hallett, M., Hampel, H., Hanoğlu, L., Haraldsen, I., Hassan, M., Hatlestad-Hall, C., Horváth, A., Ibanez, A., Infarinato, F., Jaramillo-Jimenez, A., Jeong, J., Jiang, Y., Kamiński, M., Koch, G., Kumar, S., Leodori, G., Li, G., Lizio, R., Lopez, S., Ferri, R., Maestú, F., Marra, C., Marzetti, L., McGeown, W., Miraglia, F., Moguilner, S., Moretti, D., Mushtaq, F., Noce, G., Nucci, L., Ochoa, J., Onorati, P., Padovani, A., Pappalettera, C., Parra, M., Pardini, M., Pascual-Marqui, R., Paulus, W., Pizzella, V., Prado, P., Rauchs, G., Ritter, P., Salvatore, M., Santamaria-García, H., Schirner, M., Soricelli, A., Taylor, J., Tankisi, H., Tecchio, F., Teipel, S., Kodamullil, A., Triggiani, A., Valdes-Sosa, M., Valdes-Sosa, P., Vecchio, F., Vossel, K., Yao, D., Yener, G., Ziemann, U. & Kamondi, A., abr. 2025, In: Clinical Neurophysiology, 172, p. 33-50.

Multilingualism protects against accelerated aging in cross-sectional and longitudinal analyses of 27 European countries</>

Amoruso, L., Hernandez, H., Santamaria-Garcia, H., Moguilner, S., Legaz, A., Prado, P., Cuadros, J., Gonzalez, L., Gonzalez-Gomez, R., Migeot, J., Coronel-Oliveros, C., Cruzat, J., Carreiras, M., Medel, V., Maito, M., Duran-Aniotz, C., Tagliazucchi, E., Baez, S., García, A. & Ibanez, A., 2025, In: Nature Aging, 5, 11, p. 2340-2354.

The exposome of healthy and accelerated aging across 40 countries</>

Hernandez, H., Santamaria-Garcia, H., Moguilner, S., Farina, F., Legaz, A., Prado, P., Cuadros, J., Gonzalez, L., Gonzalez-Gomez, R., Migeot, J., Coronel-Oliveros, C., Tagliazucchi, E., Maito, M., Godoy, M., Cruzat, J., Shaheen, A., Farombi, T., Salazar, D., Da Ros, L., Borelli, W., Zimmer, E., Njamnshi, A., Bajpai, S., Dey, A., Mostert, C., Merali, Z., Salama, M., Moustafa, S., Fittipaldi, S., Altschuler, F., Medel, V., Huepe, D., Yaffe, K., Momoh, C., Eyre, H., Swieboda, P., Lawlor, B., Miranda, J., Duran-Aniotz, C., Baez, S. & Ibanez, A., 2025, In: Nature Medicine.

Biophysical models applied to dementia patients reveal links between geographical origin, gender, disease duration, and loss of neural inhibition</>

Moguilner, S., Herzog, R., Perl, Y., Medel, V., Cruzat, J., Coronel, C., Kringelbach, M., Deco, G., Ibáñez, A. & Tagliazucchi, E., dic. 2024, In: Alzheimer's Research and Therapy, 16, 1.

Gaming expertise induces meso‑scale brain plasticity and efficiency mechanisms as revealed by whole-brain modeling</>

Coronel-Oliveros, C., Medel, V., Orellana, S., Rodiño, J., Lehue, F., Cruzat, J., Tagliazucchi, E., Brzezicka, A., Orio, P., Kowalczyk-Grębska, N. & Ibáñez, A., jun. 2024, In: NeuroImage, 293.

Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas</>

Legaz, A., Altschuler, F., Gonzalez-Gomez, R., Hernández, H., Baez, S., Migeot, J., Fittipaldi, S., Medel, V., Maito, M., Godoy, M., Moguilner, S., Cruzat, J., Coronel-Oliveros, C., Tagliazuchi, E., Santamaria Garcia, H., Farina, F., Reyes, P., Javandel, S., García, A., Deleglise, Á., Matallana, D., Avila-Funes, J., Slachevsky, A., Behrens, M., Custodio, N., Trujillo-Llano, C., Cardona, J., Barttfeld, P., Brusco, I., Bruno, M., Sosa Ortiz, A., Pina-Escudero, S., Takada, L., França Resende, E., Possin, K., Okada de Oliveira, M., Hu, K., Lopera, F., Lawlor, B., Valcour, V., Yokoyama, J., Miller, B. & Ibañez, A., 2024, In: Nature Aging, 5, 2, p. 259-274.

Correction to</>

Moguilner, S., Baez, S., Hernandez, H., Migeot, J., Legaz, A., Gonzalez-Gomez, R., Farina, F., Prado, P., Cuadros, J., Tagliazucchi, E., Altschuler, F., Maito, M., Godoy, M., Cruzat, J., Valdes-Sosa, P., Lopera, F., Ochoa-Gómez, J., Hernandez, A., Bonilla-Santos, J., Gonzalez-Montealegre, R., Anghinah, R., d’Almeida Manfrinati, L., Fittipaldi, S., Medel, V., Olivares, D., Yener, G., Escudero, J., Babiloni, C., Whelan, R., Güntekin, B., Yırıkoğulları, H., Santamaria-Garcia, H., Lucas, A., Huepe, D., Di Caterina, G., Soto-Añari, M., Birba, A., Sainz-Ballesteros, A., Coronel-Oliveros, C., Yigezu, A., Herrera, E., Abasolo, D., Kilborn, K., Rubido, N., Clark, R., Herzog, R., Yerlikaya, D., Hu, K., Parra, M., Reyes, P., García, A., Matallana, D., Avila-Funes, J., Slachevsky, A., Behrens, M., Custodio, N., Cardona, J., Barttfeld, P., Brusco, I., Bruno, M., Sosa Ortiz, A., Pina-Escudero, S., Takada, L., Resende, E., Possin, K., de Oliveira, M., Lopez-Valdes, A., Lawlor, B., Robertson, I., Kosik, K., Duran-Aniotz, C., Valcour, V., Yokoyama, J., Miller, B. & Ibanez, A., 2024, In: Nature Medicine, 30, 12, p. 3779.

Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations</>

Moguilner, S., Baez, S., Hernandez, H., Migeot, J., Legaz, A., Gonzalez-Gomez, R., Farina, F., Prado, P., Cuadros, J., Tagliazucchi, E., Altschuler, F., Maito, M., Godoy, M., Cruzat, J., Valdes-Sosa, P., Lopera, F., Ochoa-Gómez, J., Hernandez, A., Bonilla-Santos, J., Gonzalez-Montealegre, R., Anghinah, R., d’Almeida Manfrinati, L., Fittipaldi, S., Medel, V., Olivares, D., Yener, G., Escudero, J., Babiloni, C., Whelan, R., Güntekin, B., Yırıkoğulları, H., Santamaria-Garcia, H., Lucas, A., Huepe, D., Di Caterina, G., Soto-Añari, M., Birba, A., Sainz-Ballesteros, A., Coronel-Oliveros, C., Yigezu, A., Herrera, E., Abasolo, D., Kilborn, K., Rubido, N., Clark, R., Herzog, R., Yerlikaya, D., Hu, K., Parra, M., Reyes, P., García, A., Matallana, D., Avila-Funes, J., Slachevsky, A., Behrens, M., Custodio, N., Cardona, J., Barttfeld, P., Brusco, I., Bruno, M., Sosa Ortiz, A., Pina-Escudero, S., Takada, L., Resende, E., Possin, K., de Oliveira, M., Lopez-Valdes, A., Lawlor, B., Robertson, I., Kosik, K., Duran-Aniotz, C., Valcour, V., Yokoyama, J., Miller, B. & Ibanez, A., 2024, In: Nature Medicine, 30, 12, p. 3646-3657.

Educational disparities in brain health and dementia across Latin America and the United States</>

Gonzalez-Gomez, R., Legaz, A., Moguilner, S., Cruzat, J., Hernández, H., Baez, S., Cocchi, R., Coronel-Olivero, C., Medel, V., Tagliazuchi, E., Migeot, J., Ochoa-Rosales, C., Maito, M., Reyes, P., Santamaria Garcia, H., Godoy, M., Javandel, S., García, A., Matallana, D., Avila-Funes, J., Slachevsky, A., Behrens, M., Custodio, N., Cardona, J., Brusco, I., Bruno, M., Sosa Ortiz, A., Pina-Escudero, S., Takada, L., Resende, E., Valcour, V., Possin, K., Okada de Oliveira, M., Lopera, F., Lawlor, B., Hu, K., Miller, B., Yokoyama, J., Gonzalez Campo, C. & Ibañez, A., 2024, In: Alzheimer's and Dementia, 20, 9, p. 5912-5925.

Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole-brain modeling</>

Coronel-Oliveros, C., Gómez, R., Ranasinghe, K., Sainz-Ballesteros, A., Legaz, A., Fittipaldi, S., Cruzat, J., Herzog, R., Yener, G., Parra, M., Aguillon, D., Lopera, F., Santamaria-Garcia, H., Moguilner, S., Medel, V., Orio, P., Whelan, R., Tagliazucchi, E., Prado, P. & Ibañez, A., 2024, In: Alzheimer's and Dementia, 20, 5, p. 3228-3250.

Source space connectomics of neurodegeneration</>

Prado, P., Moguilner, S., Mejía, J., Sainz-Ballesteros, A., Otero, M., Birba, A., Santamaria-Garcia, H., Legaz, A., Fittipaldi, S., Cruzat, J., Tagliazucchi, E., Parra, M., Herzog, R. & Ibáñez, A., abr. 2023, In: Neurobiology of Disease, 179.

Model-based whole-brain perturbational landscape of neurodegenerative diseases</>

Perl, Y., Fittipaldi, S., Campo, C., Moguilner, S., Cruzat, J., Fraile-Vazquez, M., Herzog, R., Kringelbach, M., Deco, G., Prado, P., Ibanez, A. & Tagliazucchi, E., mar. 2023, In: eLife, 12.

Temporal Irreversibility of Large-Scale Brain Dynamics in Alzheimer's Disease</>

Cruzat, J., Herzog, R., Prado, P., Sanz-Perl, Y., Gonzalez-Gomez, R., Moguilner, S., Kringelbach, M., Deco, G., Tagliazucchi, E. & Ibañez, A., mar. 2023, In: Journal of Neuroscience, 43, 9, p. 1643-1656.

Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain’s control energy landscape</>

Singleton, S., Luppi, A., Carhart-Harris, R., Cruzat, J., Roseman, L., Nutt, D., Deco, G., Kringelbach, M., Stamatakis, E. & Kuceyeski, A., dic. 2022, In: Nature Communications, 13, 1.

Genuine high-order interactions in brain networks and neurodegeneration</>

Herzog, R., Rosas, F., Whelan, R., Fittipaldi, S., Santamaria-Garcia, H., Cruzat, J., Birba, A., Moguilner, S., Tagliazucchi, E., Prado, P. & Ibanez, A., dic. 2022, In: Neurobiology of Disease, 175.

Effects of classic psychedelic drugs on turbulent signatures in brain dynamics</>

Cruzat, J., Perl, Y., Escrichs, A., Vohryzek, J., Timmermann, C., Roseman, L., Luppi, A., Ibañez, A., Nutt, D., Carhart-Harris, R., Tagliazucchi, E., Deco, G. & Kringelbach, M., oct. 2022, In: Network Neuroscience, 6, 4, p. 1104-1124.

Multi-feature computational framework for combined signatures of dementia in underrepresented settings</>

Moguilner, S., Birba, A., Fittipaldi, S., Gonzalez-Campo, C., Tagliazucchi, E., Reyes, P., Matallana, D., Parra, M., Slachevsky, A., Farías, G., Cruzat, J., García, A., Eyre, H., La Joie, R., Rabinovici, G., Whelan, R. & Ibáñez, A., ago. 2022, In: Journal of neural engineering, 19, 4.

Dementia ConnEEGtome</>

Prado, P., Birba, A., Cruzat, J., Santamaría-García, H., Parra, M., Moguilner, S., Tagliazucchi, E. & Ibáñez, A., feb. 2022, In: International Journal of Psychophysiology, 172, p. 24-38.

Allostatic-Interoceptive Overload in Frontotemporal Dementia</>

Birba, A., Santamaría-García, H., Prado, P., Cruzat, J., Ballesteros, A., Legaz, A., Fittipaldi, S., Duran-Aniotz, C., Slachevsky, A., Santibañez, R., Sigman, M., García, A., Whelan, R., Moguilner, S. & Ibáñez, A., 2022, In: Biological Psychiatry, 92, 1, p. 54-67.

The phase of Theta oscillations modulates successful memory formation at encoding</>

Cruzat, J., Torralba, M., Ruzzoli, M., Fernández, A., Deco, G. & Soto-Faraco, S., abr. 2021, In: Neuropsychologia, 154.

Dynamic coupling of whole-brain neuronal and neurotransmitter systems</>

Kringelbach, M., Cruzat, J., Cabral, J., Knudsen, G., Carhart-Harris, R., Whybrow, P., Logothetis, N. & Deco, G., abr. 2020, In: Proceedings of the National Academy of Sciences of the United States of America, 117, 17, p. 9566-9576.

Brain songs framework used for discovering the relevant timescale of the human brain</>

Deco, G., Cruzat, J. & Kringelbach, M., dic. 2019, In: Nature Communications, 10, 1.

Awakening</>

Deco, G., Cruzat, J., Cabral, J., Tagliazucchi, E., Laufs, H., Logothetis, N. & Kringelbach, M., sep. 2019, In: Proceedings of the National Academy of Sciences of the United States of America, 116, 36, p. 18088-18097.

Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD</>

Deco, G., Cruzat, J., Cabral, J., Knudsen, G., Carhart-Harris, R., Whybrow, P., Logothetis, N. & Kringelbach, M., oct. 2018, In: Current Biology, 28, 19, p. 3065-3074.e6.

The dynamics of human cognition</>

Cruzat, J., Deco, G., Tauste-Campo, A., Principe, A., Costa, A., Kringelbach, M. & Rocamora, R., may. 2018, In: NeuroImage, 172, p. 492-505.

Whole network, temporal and parietal lobe contributions to the earliest phases of language production</>

Principe, A., Calabria, M., Campo, A., Cruzat, J., Conesa, G., Costa, A. & Rocamora, R., oct. 2017, In: Cortex, 95, p. 238-247.